Active Pharmaceutical Ingredients
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Micromeritics – Particle Size Instrument Solutions

Particle Size Instrument Solutions

Micromeritics – Particle Size Instrument Solutions

Micromeritics Instruments Corporation is a global provider of particle size instrument solutions for material characterization with best-in-class instrumentation and application expertise in five core areas: density; surface area and porosity; particle size instrument solutions and shape; powder characterization; and catalyst characterization and process development. Founded in 1962, the company has headquarters in Norcross, Georgia, USA and more than 300 employees worldwide. Contract testing is offered via the Particle Testing Authority (PTA).

Micromeritics serves industries from oil processing to pharmaceuticals and works at the forefront of characterization technology for next generation materials such as metal-organic-frameworks and nanocatalysts. Engineering optimal solutions for every user is a defining company characteristic.

Particle Size Instrument Solutions

There are a number of techniques by which to determine the quantity vs. equivalent size distribution of a collection of particle size. Selecting the right technique is critical in obtaining reliable data. No single technique is appropriate for all materials or applications. For this reason, Micromeritics offers you six different particle size instrument solutions, each employing different analytical techniques, to fit your application.

Dynamic Light Scattering for Nano particle Size and Zeta Potential

Instruments in the Zetasizer range are used to measure particle size from less than a nanometer to several microns using dynamic light scattering; zeta potential and electrophoretic mobility using electrophoretic light scattering; and molecular weight using static light scattering.

  • 4 product models ranging from new, market leading, innovative technology to world’s most popular, value-oriented DLS systems, enabling customers to choose the best match for their application needs
  • Unique capabilities including MADLS, Particle Concentration, Microrheology and other capabilities only available in Zetasizer systems
  • Unprecedented ease of use and flexibility along with empowering user guidance and novel measurement techniques
  • Wide variety of accessories, cells and cuvettes to ensure optimal results for your applications
  • Measure the zeta potential of samples with little or no dilution in the Zetasizer Nano ZS with a high concentration cell


Particle Size Instrument Solutions – Air Permeability

This technique uses the principle of pressure drop across a packed bed of powder. By varying the sample height, and hence the “porosity” of the bed, average surface area and particle size instrument can be determined as a function of pressure drop and flow rate in accordance with the Carmen equation.

The Micromeritics SAS is a modernized and improved version of the Fisher Model 95 Sub-Sieve Sizer. The SAS has drastically improved the well-established air-permeability particle size technique. Air-permeability techniques generate average specific surface area data for powder samples. The specific surface area of particles has a significant impact on the physical properties of powders and has been the focus of much attention from pharmaceutical, paint, toner, and geological applications.

  • Measures particle size instrument solutions in a range of 0.2 – 75 μm
  • Designed to generate “Fisher number” results identical to that of its predecessor, the Fisher Sub-Sieve Sizer
  • Simple set-up and real time data display

Particle Size Instrument Solutions – The Electrical Sensing Zone

The electrical sensing zone (ESZ) technique, also known as the Coulter principle, analyzes samples the size particle by particle. Requiring only a small volume of sample for analysis, it provides the highest particle size measurement resolution of the techniques presented here. A homogeneously dispersed suspension of sample material is prepared in an electrolytic solution. A tube with a small orifice of short path length is submerged in the suspension, an electrode being positioned on both sides of the orifice. A pump establishes a flow of electrolyte through the orifice, providing a conductive path between the two electrodes and a small electrical current is established between them. Both electrolyte and particles pass through the orifice. The particles, being non-conductive, impede the electrical current flow as they enter the orifice. This creates an electrical signal proportional to the volume of the particle. Each individual particle is counted and classified according to volume, thus producing a volume frequency distribution. The particles are considered to be spherical and a particle diameter can be determined from volume.

Unlike other measurement techniques, the electrical sensing zone method can size samples that have assorted optical properties, densities, colors, and shapes. The Elzone II can determine the size, number, concentration, and mass of innumerable organic and inorganic materials.

  • Sizes and counts both organic and inorganic materials from 0.4 to 266 μm
  • Different conductive liquids can be used without needing to enter an extensive set of liquid properties
  • Does not require previous knowledge of material properties (density, refractive index)
  • Automated features include: start-up, run, and shut-down routines; blockage detection and clearing; flushing/rinsing; and calibration
  • A CCD camera provides real-time video display of the aperture to assure a clear path through the detection zone


Particle Size Instruments


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